Be aware of your surroundings in the .037 seconds that you are making the decision to defend your life I wouldn't choose a shot gun but if I had to choose a shot gun I would also wish there was a slug in it or 000 buck, after all I am defending my life I want to kill what ever it is I am shooting at, and yes not miss g would help alleviate all consern about over penetration. .380 would do me fine for home defense